Seleccionar página

The revolution and evolution in nanotechnology carriers.

Who we are

Lifesome Therapeutics is a start-up based in Madrid, dedicated to manufacturing and supplying the next generation of therapeutic drug delivery for a personalized medicine. With over 18 years of expertise, our globally acclaimed scientists focus on creating innovative carriers for oncology, vaccines, antimicrobial agents, and molecular biomarkers

Our purpose

(to) Radically improve the standard in drug delivery to transform people’s lives.

Our vision

Lead the paradigm shift in nanotechnology carriers to boost precision medicine.

Our values

State-of-the-art

We foster creativity and curiosity to find solutions for incurable diseases, turning complex challenges into opportunities for success.

Synergy

We pursue a shared goal, fueled by collective effort. Progress made by each one benefits all.

Commitment

We understand people’s needs and work with precision to create tailored solutions.

Responsive

Our flexible approach allows us to tackle modern medical challenges, leveraging available resources to achieve optimal results.

Rigor

We uphold high-quality standards at every stage of the scientific process, ensuring accuracy and delivering effective products that fulfill their promises.

Lifesome in numbers

Patents

Scientific papers

Collaborations

Our team

Jean-Marie Ruysschaert

Co-founder and COO
+ more

Christophe Vandier

Co-founder and CTO
+ more

Ana Bouchet

Co-founder and CEO
+ more

Luis Tebar

Research Scientist
+ more

Natalia Alfaro

Research Scientist
+ more

Diego Pazos

Research Scientist
+ more

Antoine Briffaux

Research Scientist
+ more

Alberto Encinas

Research Scientist
+ more

Advisory Board

Prof. Thierry Lecomte, MD., PhD.

Oncology Expert
Expert in Hepatogastroenterology and Digestive Oncology

Julio Martin, PhD.

Life Science Expert
Life Science and Pharma R&D expert

Prof. Paul-Alain Jaffres, PhD.

Organic Chemistry, Health and Materials Expert Lipid chemistry, gene delivery and hybrid materials expertise

Key references

1. Coune A., Sculier J.P., Hildebrand J., Frühling J., Strijkmans P., Brassine C., Ghanem G., Ruysschaert J.-M. and Atassi G.(1983).»Iv administration of a water-insoluble antimitotic compound entrapped in liposomes.Preliminary report on infusion of large volumes of liposomes to man. Cancer Treat. Rep., 67(11): 1031-1033.

3

2. Bery, F., Cancel, M., Guéguinou, M., Potier-Cartereau, M., Vandier, C., Chantôme, A., Guibon, R., Bruyère, F., Fromont, G., Mahéo, K. (2021). Zeb1 and SK3 Channel Are Up-Regulated in Castration-Resistant Prostate Cancer and Promote Neuroendocrine Differentiation. Cancers, 13, 2947.
3. Bauduin, A., Papin, M., Chantôme, A., Couthon, H., Deschamps, L., Requejo-Isidro, J., … Vandier, C. & Jaffres, P. A. (2021). Development of pyrene-based fluorescent ether lipid as inhibitor of SK3 ion channels. European Journal of Medicinal Chemistry, 209, 112894.
4. Figiel, S., Bery, F., Chantôme, A., Fontaine, D., Pasqualin, C., Maupoil, V., Vandier, C…. & Mahéo, K. (2019). A novel calcium-mediated EMT pathway controlled by lipids: An opportunity for prostate cancer adjuvant therapy. Cancers, 11(11), 1814.
5. Sevrain, C. M., Fontaine, D., Bauduin, A., Guéguinou, M., Zhang, B. L., Chantôme, A.,…Vandier, C. & Jaffres, P. A. (2021). Thio-ether functionalized glycolipid amphiphilic compounds reveal a potent activator of SK3 channel with vasorelaxation effect. Organic & Biomolecular Chemistry, 19(12), 2753-2766.
6. Rua, C., Guéguinou, M., Soubai, I., Viel, E., Potier-Cartereau, M., Chantome, A., … & Vandier, C. (2018). SK3 gene polymorphism is associated with taxane neurotoxicity and cell calcium homeostasis. Clinical Cancer Research, 24(21), 5313-5320.
7. Herrera, F. E., Sevrain, C. M., Jaffrès, P. A., Couthon, H., Grélard, A., Dufourc, E. J.,Vandier, C. … & Bouchet, A. M. (2017). Singular interaction between an antimetastatic agent and the lipid bilayer: The Ohmline case. ACS omega, 2(10), 6361-6370.
8. Guéguinou, M., Felix, R., Marionneau-Lambot, S., Oullier, T., Penna, A., Kouba, S., Bouchet, A. M., Vandier, C…. & Potier-Cartereau, M. (2021). Synthetic alkyl-ether-lipid promotes TRPV2 channel trafficking trough PI3K/Akt-girdin axis in cancer cells and increases mammary tumour volume. Cell Calcium, 97, 102435.
9. Berthe, W., Sevrain, C. M., Chantôme, A., Bouchet, A. M., Gueguinou, M., Fourbon, Y.,Vandier, C. … & Jaffrès, P. A. (2016). New disaccharide‐based ether lipids as SK3 ion channel inhibitors. ChemMedChem, 11(14), 1531-1539.
10. Papin, M., Bouchet, A. M., Chantôme, A., & Vandier, C. (2023). Ether-lipids and cellular signaling: A differential role of alkyl-and alkenyl-ether-lipids. Biochimie.
11. Lonez, C., Vandenbranden, M., & Ruysschaert, J.-M. (2008). Cationic liposomal lipids: from gene carriers to cell signaling. Progress in lipid research, 47(5), 340-347.
12. Sevrain, C. M., Haelters, J. P., Chantôme, A., Couthon-Gourvès, H., Gueguinou, M., Potier-Cartereau, M., … Vandier, C.& Jaffrès, P. A. (2013). DiGalactosyl-Glycero-Ether Lipid: Synthetic approaches and evaluation as SK3 channel inhibitor. Organic & Biomolecular Chemistry, 11(27), 4479-4487.
13. Chantôme, A., Potier-Cartereau, M., Clarysse, L., Fromont, G., Marionneau-Lambot, S., Guéguinou, M., … & Vandier, C. (2013). Pivotal role of the lipid Raft SK3–Orai1 complex in human cancer cell migration and bone metastases. Cancer research, 73(15), 4852-4861.
14. Gueguinou, M., Crottès, D., Chantôme, A., Rapetti-Mauss, R., Potier-Cartereau, M., Clarysse, L., … Vandier, C. & Soriani, O. (2017). The SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca2+ homeostasis. Oncogene, 36(25), 3640-3647.
15. Potier, M., Joulin, V., Roger, S., Besson, P., Jourdan, M. L., LeGuennec, J. Y., … & Vandier, C. (2006). Identification of SK3 channel as a new mediator of breast cancer cell migration. Molecular cancer therapeutics, 5(11), 2946-2953.
16. Guéguinou, M., Harnois, T., Crottes, D., Uguen, A., Deliot, N., Gambade, A.,Vandier, C. … & Potier-Cartereau, M. (2016). SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: A novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline. Oncotarget, 7(24), 36168.
17. Jaffres, P. A., Gajate, C., Bouchet, A. M., Couthon-Gourves, H., Chantôme, A., Potier-Cartereau, M., … & Vandier, C. (2016). Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy. Pharmacology & Therapeutics, 165, 114-131.
18. Gueguinou, M., Gambade, A., Félix, R., Chantôme, A., Fourbon, Y., Bougnoux, P., … & Vandier, C. (2015). Lipid rafts, KCa/ClCa/Ca2+ channel complexes and EGFR signaling: Novel targets to reduce tumor development by lipids. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1848(10), 2603-2620.
19. Girault, A., Haelters, J. P., Potier-Cartereau, M., Chantôme, A., Pinault, M., Marionneau-Lambot, S., … & Vandier, C. (2011). New alkyl-lipid blockers of SK3 channels reduce cancer cell migration and occurrence of metastasis. Current cancer drug targets, 11(9), 1111-1125.
20. Lonez C, Vandenbranden M, Ruysschaert J.-M.. (2012) Cationic lipids activate intracellular signaling pathways. Adv Drug Deliv Rev. 64(15):1749-58.
21. Martín E. Villanueva, Laure Bar, Lorena Redondo-Morata, Peter Namdar, Jean-Marie Ruysschaert, Georg Pabst, Christophe Vandier, Ana María Bouchet, Patricia Losada-Pérez,
Spontaneous nanotube formation of an asymmetric glycolipid, Journal of Colloid and Interface Science, Volume 671, 2024, Pages 410-422, ISSN 0021-9797,
https://doi.org/10.1016/j.jcis.2024.05.132.
(https://www.sciencedirect.com/science/article/pii/S0021979724011184)